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These factors trigger the release of chemokines and complement fixation, attracting inflammatory cells to concentrate in the joints of affected individuals [61]

Peptide therapy involves the delivery of bioactive peptides that work at the cellular level to promote healing, regeneration, and optimal function

It has been illustrated that p53 serves as a critical non-histone protein substrate of HDAC4 and involves in neuronal death signaling following epileptic seizures [108]

The effects of metformin, a first-line medication for type 2 diabetes, on OA and its underlying mechanisms remain obscure

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The fluorescence intensity of DCF was measured using a Tecan microplate reader at predetermined time points ( ex = 490 10 nm, em = 525 20 nm)